Dee Ann Casteel, Ph. D.

Associate Professor of Chemistry

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Department of Chemistry
Bucknell University
Lewisburg PA 17837

phone 717/524-3675

fax 717/524-1739

casteeel@bucknell.edu

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Courses Taught

CH211 Organic Chemistry I

every fall semester

9:30am - 11:00am Tuesdays and Thursdays

CH212 Organic Chemistry II

every spring semester

9:30am - 11:00am Tuesdays and Thursdays

CH361 Mechanisms of Organic Reactions

fall semester 1995, 1996

CH329 Advanced Organic Synthesis

spring semester 1998, 1999

CH351 Chemistry Seminar

spring semester 1997

Research Interests

organic synthesis

hetero-Diels-Alder preparation of substituted dihydropyrans

preparation of organic peroxides

synthesis of analogs of artemisinin

antimalarial compounds

artemisinin analogs

bicyclic trioxanes

peroxides

synthesis

biological activity

natural products

peroxy

biologically active

medicinal chemistry

antimalarial, antitumor, antiviral

Publications

"The Chemistry of Natural Products" (book review)
Casteel, D. A.
Journal of the American Chemical Society 1995, 117, (24) in press [The Chemistry of Natural Products. Edited by R. H. Thomson (University of Aberdeen). Blackie Academic & Professional: London. 1993. x + 452 $149.95. ISBN 0-7514-0014-9].

"Prolongation of the Intravascular Retention of Hemoglobin Modified with a Long-Chain Fatty Acid Derivative"
Fowler, S. A.; Andracki, J.; Hurst, G.; Honkan, V. A.; Walder, J.; Casteel, D. A.
Biomaterials, Artificial Cells and Immobilization Biotechnology, 1994, 22, 27-42.

"Synthesis and Antimalarial Evaluation of 2,3,5-Trioxabicyclo[2.2.3]nonanes, Models for the Putative Pharmacophore of Artemisinin"
Casteel, D. A.; Peri, S. P.
Bioorganic and Medicinal Chemistry Letters 1993, 3, 1707-1710.

"Anomalous 'Lossen-Type' Rearrangement. Synthesis of Functionalized Imidazolinones"
Casteel, D. A.; Gephart, R. S.; Morgan, T.
Heterocycles 1993, 36 (3), 485-495.

"Synthesis and Antimalarial Evaluation of 2,3,5-Trioxabicyclo[2.2.2]octanes, Models for the Putative Pharmacophore of Qinghaosu (Artemisinin)"
Casteel, D. A.; Jung, K.-E.; Gerena, L.; Milhous, W.
Bioorganic and Medicinal Chemistry Letters 1992, 2, 623-626.

"Peroxy Natural Products"
Casteel, D. A.
Natural Product Reports 1992, 9, 289-312.

"Steric and Electronic Effects in the Arylphosphate to Arylphosphonate Rearrangement"
Casteel, D. A.*; Peri, S. P.
Synthesis 1991, 691-693.

"Improved Synthesis of Secondary Hydroperoxides"
Casteel, D. A.; Jung, K.-E.
Journal of the Chemical Society, Perkin Transactions I, 1991, 2597-2598.

"Isoquinoline Quinones. Preparation of Saframycin Intermediates and a Total Synthesis of Mimosamycin"
Parker, K. A.; Casteel, D. A.
Journal of Organic Chemistry 1988, 53, 2847-2850

. "Synthesis of Properties of Pyrrolo[3,4-d]imidazoles. A New Fluorescent Heterocyclic System"
Casteel, D. A.; Leonard, N. J.
Journal of Organic Chemistry 1985, 50, 2450-2456.

"Synthesis of Properties of Pyrrolo[3,4-d]imidazoles. A New Fluorescent Heterocyclic System"
Casteel, D. A.
Ph. D. Dissertation, University of Illinois at Urbana-Champaign, University Microfilms, 1985.