NMR and Biophysics Research
Department of Chemistry
Bucknell University


Nuclear magnetic resonance (NMR) is a technique for determining the shapes and structures of molecules and their interactions. NMR succeeds in discovering the structural characteristics of molecules by observing weak signals from nuclei containing a magnetic property termed ‘spin’.

Fall '14 Crew : (group alums)

Rajasri Alaparthi (B.S. '17) - metabolomics
D. Levi Craft - (Eng '17) - sampling
Reilly Sonstrom (Bioch '16) - proteins

Matthew M. Miele (MS '15) - metabolomics
Ross Pirnie (Bioch '17) - micelles*
Shauna Anderson (MS '15) - micelles*
(*with Strein lab)

SUMMER 2014 Crew!
Group Photo Summer 2014
(Matt Miele, Levi Craft, Broc Wenrich, Reilly Sonstrom, Rajasri Alaparthi, D. Rovnyak)

SUMMER 2014 Sigma Xi
Levi Craft Sigma Xi 2014  Matt Miele Sigma Xi 2014  Rajasri Alaparthi Sigma Xi 2014  Reilly Sonstrom Sigma Xi 2014

ENC 2013 Pictures!


 David Rovnyak
  Associate Professor
  Rooke 215
    Department of Chemistry
    Bucknell University
    1 Dent Drive
    Lewisburg, PA 17837

    D. Rovnyak home page
    NEPA NMR Conference
    Downloads : NMR Education


Recent Publications:

Melissa R. Palmer, Broc R. Wenrich, Phillip Stahlfeld, David Rovnyak, “Performance tuning non-uniform sampling for sensitivity enhancement of signal-limited biological NMR”, J. Biomol. NMR 58(4): 303-314, (2014). Abstract.

Brian W. Williams and David Rovnyak, “A closed-form solution for the optimal time evolution of an exponentially decaying signal with thermal noise”, Concepts in Magnetic Resonance A 43(2): 54-56 (2014). Abstract.

Christopher L. Suiter, Sivakumar Paramasivam, Guangjin Hou, Shangjin Sun, David Rice, Jeffrey C. Hoch, David Rovnyak, Tatyana Polenova, “Sensitivity gains, linearity and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range”, J. Biomol. NMR 59: 57-73, (2014).

Tinoco, Sauer, Wang, Puglisi, Harbison, Rovnyak, Physical Chemistry: Principles and Applications in the Life Sciences. 5'th Edition, (2013) Pearson. On Amazon.

Sivakumar Paramasivam, Suiter, C.L., Hou, G., Sun, S., Palmer, M., Hoch, J. C., Rovnyak, D. and Tatyana Polenova,” Enhanced Sensitivity by Nonuniform Sampling Enables Multidimensional MAS NMR Spectroscopy of Protein Assemblies“ J. Phys. Chem. B 116(25): 7416-7427 (2012). Abstract.

Rovnyak, D., Sarcone, M.S., Jiang, Z.,"Sensitivity Enhancement for Maximally Resolved Two-Dimensional NMR Spectra by Nonuniform Sampling" Magnetic Resonance in Chemistry 49(8), 483-491 (2011). Online

Kennedy, P.E, Francis, N., Rovnyak, D., Kastner, M.E., "Redetermination of cis-diaquadiglycolatozinc(II)", Acta Crystallographica Section E: Structure Reports Online E64, 1635 (2008). Online

D. Rovnyak, Kennedy, P.E, "Application of shaped adiabatic pulses to MQMAS spectrsoscopy of Spin 3/2 nuclei", Journal of Magnetic Resonance, 196, 191-199 (2009). DOI

Christine M. Hebling, Laura E. Thompson, Kyle W. Eckenroad, Gregory A. Manley, Roderick A. Fry, Karl T. Mueller, Timothy G. Strein, David Rovnyak, "Sodium Cholate Aggregation and Chiral Recognition of the Probe Molecule (R,S) 1,1’-binaphthyl-2,2’ diylhydrogenphosphate (BNDHP) Observed by 1H and 31P NMR Spectroscopy", Langmuir, 24, 13866-13874 (2008). Abstract

D. Rovnyak,"Tutorial on analytic theory for cross polarization in solid state NMR", Concepts Magn. Reson. Part A, 32, 254-276 (2008).

D. Rovnyak, R. Stockland Jr., Eds,"Modern NMR Spectroscopy in Education", American Chemical Society Symposium Seres No. 969, Oxford University Press (2007). (on Amazon)

(Full publications list)

Group Alumni:

   Claire Ouimet - (B.S. 2014)
   Riju Gupta - (BS '14)
   Broc Wenrich (M.S. '14, TCMC)

   Melissa Palmer (B.S. '13, Engineer with  Picarro, San Francisco)
  Kendall Sandy (B.S. '13, Univ. Arizona)
  Adam Meier (B/S/ '13 w/ Strein lab, Univ. Arizona)

  Paris Barkan (Neuro '12, premed)
  Brandy Taylor (M.S. Chem '12, TBA)
  Broc Wenrich

  Thomas Mann (CHM '11, Stanford)


  Mark Sarcone (Bio '10)
  Lauren Manning (Bioch '10, Univ. Penn.)

  Will Tsai (CHM '09)
  Ze Jiang (CHM/MATH '09)
  Alyson Cobb (CHM '09)

  Paul Kennedy(M.S. '10, Penn State)
  Greg Manley (CHM '08, Yale Ph.D.)
  Jayne Kubat (CHM '08, Cornell DVM)
  Meghan Monaghan (CHM '08, Washington & Lee Law)

  Kyle Eckenroad (M.S. CHEM '07, Merck)
  Katie Selzler (BIO '07, Rochester Neuro. Ph.D.)
  Summer '07 Pic

  Lindsay Morris (CHM '06, ???)
  Laura Thompson (CHM '06, Ph.D. Univ. of Md)
  Matt Mosellen (CHM '06, George Mason Law)
  Michael Heinrich (CHM '06, Univ. Penn.)
  Brian Wilson (M.S. '06, Notre Dame)
  Jeff Stoltzfus (EE '06, ???)
  Summer '06 Pic

  Jamie Brown (BIO '04, ???)

Great blog on elucidation and education.



We are a biophysical research group specializing in the application of nuclear magnetic resonance spectroscopy to biological problems. We are active in the following areas:

1. We perform fundamental studies with solid state zinc NMR spectroscopy and X-ray crystallography in collaboration with the Kastner lab. Zinc-67 is one of the most difficult of all NMR nuclei to study! See also (4).


2. We collaborate with the Strein lab to understand the chirally selective solvation of binaphthyl compounds by bile salt micelles. This project includes fundamental studies to gain deeper insight into micelle formation by bile salts.


3. We develop and disseminate laboratory and course experiences that effectively introduce undergraduate students to NMR. See our NMR Education Link for more info and dowloads.


4. We are investigating the use of alternative data sampling and processing to accelerate and enhance the acquisition of multi-dimensional NMR data.


  NMR Blogs & Links

         Stan's NMR Blog
         Ottawa NMR -Glenn Facey
         Windsor blog -Schurko lab
         NMR periodic table.
         NMR Information Server.
         Listen to NMR data
         ENC Conference