Group Page (DSR Lab)
Bucknell Chem. Dept.
Downloads : NMR Education

David Rovnyak

Research Area: Biophysical Chemistry

Professor of Chemistry
Department of Chemistry
Bucknell University
Lewisburg, PA 17837

drovnyak AT bucknell DOT edu
Rooke 215
Office : 570-577-3676
FAX : 570-577-1739 (chem dept.)

          courses : research : recent publications


2001-2003: Fellow of the National Cancer Institute at Harvard Medical School, (NRSA Award, National Institutes of Health)
2000: Harvard Medical School (G. Wagner) Postdoctoral Fellow 2000
1999-2000: Massachusetts Institute of Technology (R.G. Griffin) Postdoctoral Assoc.
1993-1999: Massachusetts Institute of Technology (R.G. Griffin) Ph.D. (Physical Chem.)
1989-1993: University of Richmond B.S. (Chemistry)

Recent and Current Teaching/Courses

Fall 2015: Physical Chemistry for Engineers (CHEM 343) and General Chemistry (CHEM 201)

See moodle/blackboard web sites for all course materials and announcements.


We puruse diverse biophysical studies usually involving nuclear magnetic resonance (NMR) spectroscopy, from human and insect metabolomics to the fundamental mathematics of the NMR signal.

Please visit the group web page for more information.

Publications: Books

[3] “Modern NMR Approaches for the Structure Elucidation of Natural Products Volume 1: Instrumentation and Software”, Antony J. Williams, Gary E. Martin, David Rovnyak, Editors. RSC Publishing, (2015). RSC and Amazon.

[2] I. Tinoco, K. Sauer, J.C. Wang, J.D. Puglisi, G. Harbison, D. Rovnyak, “Physical Chemistry: Principles and Applications in Biological Sciences”, 5’th edition, Pearson, (2013). Amazon.

[1] D. Rovnyak, R. Stockland Jr., Eds."Modern Nuclear Magnetic Resonance Spectroscopy in Education", American Chemical Society Symposium Series Book, Oxford University Press. (2007). ACS Books.

Publications: Articles (undergraduate coauthor, *MS coauthor)

[31] Melissa Palmer, Gupta, R., Richard, M., Suiter, C.L., Hoch, J.C., Polenova, T., Rovnyak, D.,”Application of nonuniform sampling for sensitivity enhancement of small molecule heteronuclear correlation NMR spectra” in “Modern NMR Approach for the Structure Elucidation of Natural Products”, Eds: Gary E. Martin, Antony J. Williams, and David Rovnyak, RSC Publishing, (2015).

[30] *Wenrich, B. R., Sonstrom, R.E., Gupta, R.A., Rovnyak, D.,"Enhanced biosynthetically directed fractionalcarbon-13 enrichment of proteins for backbone NMR assignments", Protein Expr Purif  115, 1-10 (2015)

[29] Palmer, M.R., Suiter, C.L., Henry, G.E., Rovnyak, J., Hoch, J.C., Polenova, T., and D. Rovnyak, “Sensitivity of Nonuniform Sampling NMR”, J. Phys. Chem. B, DOI: 10.1021/jp5126415 (2015).

[28] Rebecca Force, Shui Ling Chen, Emily Fortier, Emily Rowlands, Jean Jeneks, David Rovnyak, and Geneive Henry,”Spirocyclin acylphloroglucinol derivatives from Hypericum pyramidatum”, Nat. Prod. Comm. 9, 889-1058 (2014).

[27] Brian W. Williams and David Rovnyak, “A closed-form solution for the optimal time evolution of an exponentially decaying signal with thermal noise”, Concepts in Magnetic Resonance A 43(2): 54-56 (2014).

[26] Melissa R. Palmer, *Broc R. Wenrich, Phillip Stahlfeld, David Rovnyak, “Performance tuning non-uniform sampling for sensitivity enhancement of signal-limited biological NMR”, J. Biomol. NMR 58(4): 303-314, (2014).

[25] Christopher L. Suiter, Sivakumar Paramasivam, Guangjin Hou, Shangjin Sun, David Rice, Jeffrey C. Hoch, David Rovnyak, Tatyana Polenova, “Sensitivity gains, linearity and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range”, J. Biomol. NMR 59: 57-73, (2014).

[24] Sivakumar Paramasivam, Suiter, C.L., Hou, G., Sun, S., Palmer, M., Hoch, J. C., Rovnyak, D. and Tatyana Polenova,” Enhanced Sensitivity by Nonuniform Sampling Enables Multidimensional MAS NMR Spectroscopy of Protein Assemblies“ J. Phys. Chem. B 116(25): 7416-7427 (2012).

[23] Rovnyak, D., Sarcone, M.S., Jiang, Z.,"Sensitivity Enhancement for Maximally Resolved Two-Dimensional NMR Spectra by Nonuniform Sampling" Magnetic Resonance in Chemistry 49(8), 483-491 (2011). Online

[22] D. Rovnyak, *Kennedy, P.E, "Application of shaped adiabatic pulses to MQMAS spectrsoscopy of Spin 3/2 nuclei", Journal of Magnetic Resonance. 96, 191-199 (2009).

[21] *Kennedy, P.E.,* Francis, N., Rovnyak, D., Kastner, M.E., "Redetermination of cis-diaquadiglycolatozinc(II)", Acta Crystallographica Section E: Structure Reports Online E64, 1635 (2008).

[20] Christine M. Hebling, Laura E. Thompson, *Kyle W. Eckenroad, Gregory A. Manley, Roderick A. Fry, Karl T. Mueller, Timothy G. Strein, David Rovnyak, "Sodium Cholate Aggregation Observed by 1H and 31P NMR Spectroscopy of the Probe Molecule (R,S) 1,1’-binaphthyl-2,2’ diylhydrogenphosphate (BNDHP)", Langmuir, 24, 13866-13874 (2008).

[19] D. Rovnyak,"Tutorial on analytic theory for cross-polarization in solid state NMR", Concepts in Magnetic Resonance Part A 32A (4), 254-276 (2008).

[18] Rovnyak, D., Thompson, L.E., Selzler, K.J., ”Experimentation with 15N enriched ubiquitin”, in Modern NMR in Education, Rovnyak, D., Stockland, R.A., eds, V969, 219-233 (2007).

[17 ] Jayne A. Kubat, J. J. Chou, D. Rovnyak,"Nonuniform sampling and maximum entropy reconstruction applied to the accurate measurement of residual dipolar couplings" J. Magn. Reson. 186, 201-211 (2007).

[16] Vladimir Gelev, Huseyin Aktas, Assen Marintchev, Takuhiro Ito, Dominique Frueh, Michael Hemond, David Rovnyak, Mirijam Debus, Sven Hyberts, Anny Usheva, Jose Halperin and Gerhard Wagner,” Mapping of the Auto-inhibitory Interactions of Protein Kinase R by Nuclear Magnetic Resonance”, J. Mol. Biol. 364, 352-363 (2006).

[15] *K. W. Eckenroad, L. E. Thompson, T.G. Strein, D. Rovnyak, "Proton NMR assignments for R,S-1,1-binaphthol (BN) and R,S-1,1-binaphthyl-2,2-diyl hydrogen phosphate (BNDHP) interacting with bile salt micelles", Magnetic Resonance in Chemistry 45, 72-75 (2006).

[14] Thompson, L.E., Rovnyak, D.,"Accessible NMR experiments studying the hydrodynamics of 15N-enriched ubiquitin at low fields", Accepted in Biochem. Molec. Biol. Ed.35, 49-56 (2006).

[13].   Zhen-Yu J. Sun, Sven G. Hyberts, David Rovnyak, Sunghyouk Park, Alan S. Stern, Jeffrey C. Hoch, Gerhard Wagner, "High-Resolution Aliphatic Side-Chain Assignments in 3D HCcoNH Experiments with Joint H-C Evolution and Non-Uniform Sampling" J. Biomol. NMR 32 (2005). 55-60.

[12].   Rovnyak, D., Thompson, L., "An Accessible Two-Dimensional Solution NMR Experiment on Human Ubiquitin", Biochem. Molec. Biol. Ed. 33 (2005), 117-122.
Abstract (BaMBEd Site)

[11].   Rovnyak, D., Hoch, J.C., Stern, A.S., Wagner, G.,"Resolution and Sensitivity of High Field Nuclear Magnetic Resonance Spectroscopy", J. Biomol. NMR 30 (2004), 1-10.
This article is a free download

[10].   Rovnyak, D., Frueh, D.P., Sastry, M., Sun, Z.-Y.J., Stern, A.S., Hoch, J.C., Wagner, G.,"Accelerated Acquisition of High Resolution Triple-Resonance Spectra Using Non-Uniform Sampling and Maximum Entropy Reconstruction", J. Magn Reson. 170 (2004), 15-21.
Abstract (doi link)

[9].   Rovnyak, D., Filip, C., Itin, B., Stern, A.S., Wagner G., Griffin, R.G., Hoch, J.C., “Multiple Quantum Magic-Angle Spinning Using Non-Linear Sampling”, J. Magn. Reson. 161 (2003), 43-55.
Abstract (doi link)

Full publications also include:
[8].   Rovnyak, D., Baldus, M., Wu, G., Hud, N.V., Feigon, J., Griffin, R.G. “Localization of 23Na+ in a DNA Quadruplex by High-Field Solid-State NMR”, J.Am.Chem.Soc. 122 (2000), 11423-11429.
Abstract (doi link)

[7].   Rovnyak, D., Baldus, M., Griffin, R.G.,”Multiple-Quantum Cross Polarization in Quadrupolar Spin Systems during Magic Angle Spinning”, J. Magn. Reson. 142 (2000) 145-152.
Abstract (doi link)

[6]     Rovnyak, D., Baldus, M., Itin, B. A., Bennati, M., Stevens, A., Griffin, R.G., “Characterization of a Carbon-Nitrogen Network Solid with NMR and High Field EPR”, J. Phys. Chem. 104 (2000) 9817-9822.
Abstract (doi link)

[5].   Baldus, M., Rovnyak, D., Griffin, R.G.,”MAS Assisted Multi-Quantum Recoupling in S=3/2 Quadrupolar Spin Systems”, J. Chem. Phys. 112 (2000) 5902-5909.
Abstract (doi link)

[4].   Wu, G., Rovnyak, D., Huang, P.C., Griffin, R.G., “High-Resolution Oxygen-17 NMR Spectroscopy of Solids by Multiple Quantum Magic-Angle Spinning”, Chem. Phys. Lett. 277 (1997) 79-83.
Abstract (doi link)

[3].   Wu, G., Rovnyak, D., et al.,”Unusual P-31 Chemical Shielding Tensors in Terminal Phosphido Complexes Containing a Phosphorous-Metal Triple Bond.”, J. Am. Chem. Soc. 118 (1996) 10654-10655.
Abstract (doi link)

[2].   Wu, G., Rovnyak, D., Griffin, R.G.,”Quantitative Multiple-Quantum Magic-Angle Spinning NMR Spectroscopy of Quadrupolar Nuclei in Solids.”, J.Am.Chem.Soc. 118 (1996) 9326-9332.
Abstract (doi link)

[1].   Wu, G., Rovnyak, D., Sun, B., Griffin, R.G.,”High–Resolution Multiple-Quantum MAS NMR Spectroscopy of Half-Integer Quadrupolar Nuclei”, Chem. Phys. Lett. 249 (1995) 210-217.
Abstract (doi link)
Erratum (eds mis-spelled my name!)