Bucknell University

Ken Field, Ph.D.
Associate Professor
Department of Biology and Cell Biology/Biochemistry Program
Bucknell University
Biology Department

Cell Biology/ Biochemistry Program
Contact Info
Ken Field, Ph.D.
203A Biology Building
Bucknell University
Lewisburg, PA 17837

570-577-3537 Fax

I am interested in the effects of farnesyltransferase inhibitors (FTIs) on the immune system in both normal and pathological conditions. I became interested in how this class of anti-cancer drugs affect the immune system while showing that these drugs can block certain immune system cancers in mice (Field et al.). My students have shown that FTIs can affect the immune regulatory proteins called cytokines that are produced by T cells in mice that are undergoing transplant rejection and that this can delay the rejection of a mismatched skin graft (Gaylo et al.). We are now trying to understand how FTI treatment affects this and other immune responses in mice in order to determine if these experimental drugs might be useful for treating transplant patients.

More information about Prof. Field's research can be found here.

Undergraduate Research
Bucknell students interested in conducting research with Prof. Field should contact him by e-mail ( ) to arrange an appointment. Opportunities are available for summer research or for Biol 399 research. Most research projects span at least two semesters and the summer so interested students should become involved in their sophomore or junior year. Students are expected to complete Cell Biology (Biol 352) and Immunology (Biol 348) while enrolled in research.

Immunology Biol 348 Development and function of the immune system in animals. The immune response in health and disease. Techniques in immunology. Lab Required. Offered Spring Semesters
Controversies in Biology Biol 111 Course for first-year students who are not science majors. Lectures introduce students to basic biology and biochemistry in order to better understand controversial topics such as animal research, genetic testing, human cloning, stem cell therapy, and the teaching of creationism. Required weekly discussion sections allow students to apply the principles learned in lecture to debate these topics. Offered Fall Semesters
Introduction to Molecules and Cells Biol 205 An introductory course which focuses on the molecular biology of cells. Basic biochemical processes, cellular and subcellular structure and function are emphasized. First core course for Biology majors and Cell Biology/Biochemistry Majors. Lab required.  
Cell Biology Biol 352 Covers biomembranes, cell growth patterns, cell signaling, the cytoskeleton, cell organelles, and microscopic technique. Laboratory includes experience with cell culture. Lab required.  

Selected Publications (Bucknell students underlined)

Gaylo AE, Laux KS, Batzel EJ, Berg ME, Field KA. 2009. Delayed rejection of MHC class II-disparate skin allografts in mice treated with farnesyltransferase inhibitors. Transplant Immunology 20(3):163-70. Full Text Article.

Field KA, Charoenthongtrakul S, Bishop JM, Refaeli Y. 2008. Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas. Molecular Cancer. 7:39. Full Text Article.

Refaeli Y, Young RM, Turner BC, Duda J, Field KA, Bishop JM. 2008. The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas. PLoS Biology. 6(6):e152. Full Text Article.

Refaeli, Y., Field, K.A,. Turner, B.C., Trumpp, A., Bishop, J.M. 2005. The protooncogene MYC can break B cell tolerance. Proceedings of the National Academy of Sciences, U.S.A. 102(11):4097-102. Full Text Article.

Field, K.A., D. Holowka, B. Baird. 1999. Structural aspects of the association of FcEpsilonRI with detergent-resistant membranes. Journal of Biological Chemistry 274:1753-1758. Full Text Article.

Field, K.A., Holowka, D., Baird, B. 1997. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. Journal of Biological Chemistry 272(7):4276-80. Full Text Article.

Field, K.A., D. Holowka, B. Baird. 1995. Fc-epsilon-RI-mediated recruitment of p53/56-lyn to detergent-resistant membrane domains accompanies cellular signaling. Proceedings of the National Academy of Sciences, U.S.A. 92 (20): 9201-9205. PDF File.

Pubmed search for KA Field.

Page maintained by Ken Field
Last updated Jan 27, 2010